The potential use of methotrexate in the treatment of falciparum malaria: in vitro assays against sensitive and multidrug-resistant falciparum strains


Dar, O; Khan, MS; Adagu, I; (2008) The potential use of methotrexate in the treatment of falciparum malaria: in vitro assays against sensitive and multidrug-resistant falciparum strains. Japanese journal of infectious diseases, 61 (3). pp. 210-1. ISSN 1344-6304

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Abstract

: The anti-malarial activity of the anti-cancer drug methotrexate against chloroquine-sensitive T9-96 and the multidrug-resistant K1 strains of Plasmodium falciparum was assessed in vitro. Mean IC50 values of 0.32 +/- 0.05 nM and 48.02 +/- 4.40 nM were obtained for T9-96 and K1, respectively, indicating methotrexate's high potency against both sensitive and resistant P. falciparum strains in vitro. Our results suggest that methotrexate is potentially effective against falciparum malaria in short-term, low-dose regimens, minimizing the risk of toxicity. This, along with the practical advantages of methotrexate, warrants the clinical investigation of methotrexate in human cases of falciparum malaria.<br/>

Item Type: Article
Keywords: MILTEFOSINE, LEISHMANIASIS, Animals, Antimalarials, pharmacology, therapeutic use, Chloroquine, pharmacology, therapeutic use, Drug Resistance, Multiple, Humans, Hypoxanthine, metabolism, Malaria, Falciparum, drug therapy, parasitology, Methotrexate, pharmacology, therapeutic use, Nucleic Acid Synthesis Inhibitors, pharmacology, therapeutic use, Parasitic Sensitivity Tests, Plasmodium falciparum, drug effects, Tritium, metabolism
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Leishmaniasis Group
Antimicrobial Resistance Centre (AMR)
PubMed ID: 18503171
Web of Science ID: 256389800009
URI: http://researchonline.lshtm.ac.uk/id/eprint/6334

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