Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam.


Van Nguyen, D; Van Nguyen, C; Bonsall, D; Ngo, TT; Carrique-Mas, J; Pham, AH; Bryant, JE; Thwaites, G; Baker, S; Woolhouse, M; Simmonds, P; (2018) Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam. Viruses, 10 (3). ISSN 1999-4915 DOI: https://doi.org/10.3390/v10030102

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Abstract

Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat,<i>Rhizomys pruinosus</i>, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the<i>Hepacivirus</i>genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Related URLs:
PubMed ID: 29495551
Web of Science ID: 428567300004
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646843

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