Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.

PRISM Investigators; Rowan, KM; Angus, DC; Bailey, M; Barnato, AE; Bellomo, R; Canter, RR; Coats, TJ; Delaney, A; Gimbel, E; +469 more... Grieve, RD; Harrison, DA; Higgins, AM; Howe, B; Huang, DT; Kellum, JA; Mouncey, PR; Music, E; Peake, SL; Pike, F; Reade, MC; Sadique, MZ; Singer, M; Yealy, DM; , COLLABORATORS; Eaton, TL; Keener, C; Landis, K; Stapleton, DK; Weissfeld, LA; Willochell, M; Wofford, KA; Kulstad, E; Watts, H; Venkat, A; Hou, PC; Massaro, A; Parmar, S; Limkakeng, ATJr; Brewer, K; Delbridge, TR; Mainhart, A; Chawla, LS; Miner, JR; Allen, TL; Grissom, CK; Swadron, S; Conrad, SA; Carlson, R; LoVecchio, F; Bajwa, EK; Filbin, MR; Parry, BA; Ellender, TJ; Sama, AE; Fine, J; Nafeei, S; Terndrup, T; Wojnar, M; Pearl, RG; Wilber, ST; Sinert, R; Orban, DJ; Wilson, JW; Ufberg, JW; Albertson, T; Panacek, EA; Parekh, S; Gunn, SR; Rittenberger, JS; Wadas, RJ; Edwards, AR; Kelly, M; Wang, HE; Holmes, TM; McCurdy, MT; Weinert, C; Harris, ES; Self, WH; Dubinski, D; Phillips, CA; Migues, RM; Cameron, PA; Holdgate, A; Webb, SA; Williams, P; Cooper, DJ; Cross, A; Gomersall, C; Graham, C; Jacobs, I; Johanson, S; Jones, P; Kruger, P; 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Parr, M; White, H; Morrison, L; Sosnowski, K; Ramadoss, R; Soar, N; Wood, J; Franks, M; Hogan, C; Song, R; Tilsley, A; Rainsford, D; Wells, R; Dowling, J; Galt, P; Lamac, T; Lightfoot, D; Walker, C; Braid, K; DeVillecourt, T; Tan, HS; Seppelt, I; Chang, LF; Cheung, WS; Fok, SK; Lam, PK; Lam, SM; So, HM; Yan, WW; Altea, A; Lancashire, B; Gomersall, CD; Graham, CA; Leung, P; Arora, S; Bass, F; Shehabi, Y; Isoardi, J; Isoardi, K; Powrie, D; Lawrence, S; Ankor, A; Chester, L; Davies, M; O’Connor, S; Poole, A; Soulsby, T; Sundararajan, K; Greenslade, JH; MacIsaac, C; Gorman, K; Jordan, A; Moore, L; Ankers, S; Bird, S; Fogg, T; Hickson, E; Jewell, T; Kyneur, K; O’Connor, A; Townsend, J; Yarad, E; Brown, S; Chamberlain, J; Cooper, J; Jenkinson, E; McDonald, E; Webb, S; Buhr, H; Coakley, J; Cowell, J; Hutch, D; Gattas, D; Keir, M; Rees, C; Baker, S; Roberts, B; Farone, E; Holmes, J; Santamaria, J; Winter, C; Finckh, A; Knowles, S; McCabe, J; Nair, P; Reynolds, C; Ahmed, B; Barton, D; Meaney, E; 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Farras-Araya, R; Vallance, D; Watt, P; Raymode, P; Hollos, L; Hopkins, P; Riozzi, P; Couper, H; Helyar, S; Thompson, J; Hales, D; Essat, Z; Andreou, P; Gilby, S; Chilton, P; Miller, R; Butler, J; Jefferies, A; Clark, R; Sanders, G; Pinto, N; Plowright, C; Innes, R; Bayford, D; Richards, P; Gopal, S; Pooni, JS; Spencer, H; Napier, J; Warrington, E; Kevern, L; Hunt, J; Barrett, C; Sykes, E; Connelly, K; Yates, B; Carle, C; Croft, T; Jenkins, N; Reschreiter, H; Camsooksai, J; Barcraft-Barnes, H; Snelson, C; Bergin, C; Keats, F; Linnett, V; Ritzema, J; Christian, S; Harvey, D; Miller, P; Woodford, C; Bolland, A; Keating, L; Mossop, D; Jones, C; Martin, D; Willett, E; Swallow, P; McBride, S; Ijaz, A; Datta, J; Craig, J; Owen, T; Williams, A; McMullan, S; Baldwin, J; Zuleika, M; Carvalho, P; Agranoff, D; Ingoldby, F; Ortiz-Ruiz De Gordoa, L; Ridley, C; Clement, I; Higham, C; Martin, B; Clayton, K; Chadwick, J; Frey, C; Miller, D; Laverick, P; Iftikhar, K; Higgins, D; Katsande, V; Chikungwa, M; Jackson, C; Watters, M; Liddiard, P; Gannon, K; Howard-Griffin, R; Bell, S; Blaylock, H; Gonzalez, I; Cirstea, E; Bonner, S; Moondi, P; Wong, K; Carter, J; Hartley, S; Crossingham, I; Hinchcliffe, J; Phoenix, L; Harris, T; Pott, J; Bellhouse, G; Mercer, M; Mercer, P; Robinson, H; Brealey, D; Ryu, J; Becardes, G; Morris, AM; Poulson, M; Barnett, L; Massey, I; Skene, I; Nee, P; Dowling, S; McCairn, A; Duckitt, R; Venn, R; Margalef, J; Redman, J; Milner, H; Ma, S; (2017) Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. The New England journal of medicine, 376 (23). pp. 2223-2234. ISSN 0028-4793 DOI: https://doi.org/10.1056/NEJMoa1701380

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