Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α(+)Thalassemia.


Etyang, AO; Khayeka-Wandabwa, C; Kapesa, S; Muthumbi, E; Odipo, E; Wamukoya, M; Ngomi, N; Haregu, T; Kyobutungi, C; Tendwa, M; Makale, J; Macharia, A; Cruickshank, JK; Smeeth, L; Scott, JA; Williams, TN; (2017) Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α(+)Thalassemia. J Am Heart Assoc, 6 (4). ISSN 2047-9980 DOI: 10.1161/JAHA.117.005613

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Abstract

: Recent studies have discovered that α-globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α(+)thalassemia, in whom the production of α-globin is reduced.<br/> : The study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty-four-hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α(+)thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (-α/αα) and 47 (8%) were homozygous (-α/-α) for α(+)thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24-hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in -α/αα, and 118±11 mm Hg in -α/-α subjects, respectively. Mean 24-hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms(-1), respectively. No differences were observed in PWV and any of the 24-hour ambulatory BP monitoring-derived measures between those with and without α(+)thalassemia.<br/> : These data suggest that the presence of α(+)thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: EHR Research Group
PubMed ID: 28381468
URI: http://researchonline.lshtm.ac.uk/id/eprint/3860824

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