Status of vaccine research and development of vaccines for Streptococcus pyogenes.


Steer, AC; Carapetis, JR; Dale, JB; Fraser, JD; Good, MF; Guilherme, L; Moreland, NJ; Mulholland, EK; Schodel, F; Smeesters, PR; (2016) Status of vaccine research and development of vaccines for Streptococcus pyogenes. Vaccine, 34 (26). pp. 2953-8. ISSN 0264-410X DOI: 10.1016/j.vaccine.2016.03.073

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Abstract

: Streptococcus pyogenes is an important global pathogen, causing considerable morbidity and mortality, especially in low and middle income countries where rheumatic heart disease and invasive infections are common. There is a number of promising vaccine candidates, most notably those based on the M protein, the key virulence factor for the bacterium. Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 27032515
Web of Science ID: 378365200018
URI: http://researchonline.lshtm.ac.uk/id/eprint/2535739

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