Chronic Infection With Camelid Hepatitis E Virus in a Liver-transplant Recipient Who Regularly Consumes Camel Meat and Milk.


Lee, GH; Tan, BH; Chi-Yuan Teo, E; Lim, SG; Dan, YY; Wee, A; Aw, PP; Zhu, Y; Hibberd, ML; Tan, CK; Purdy, MA; Teo, CG; (2015) Chronic Infection With Camelid Hepatitis E Virus in a Liver-transplant Recipient Who Regularly Consumes Camel Meat and Milk. Gastroenterology, 150 (2). 355-7.e3. ISSN 0016-5085 DOI: https://doi.org/10.1053/j.gastro.2015.10.048

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Abstract

: There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared it with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, therefore camelid HEV, which is genotype 7, might infect human beings. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26551551
Web of Science ID: 368629900022
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534029

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