Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia.


Fornace, KM; Nuin, NA; Betson, M; Grigg, MJ; William, T; Anstey, NM; Yeo, TW; Cox, J; Ying, LT; Drakeley, CJ; (2015) Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia. The Journal of infectious diseases, 213 (5). pp. 784-7. ISSN 0022-1899 DOI: 10.1093/infdis/jiv475

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Abstract

: Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 26433222
Web of Science ID: 372438300015
URI: http://researchonline.lshtm.ac.uk/id/eprint/2319295

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