Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats


Thomasson, D; Wright, EA; Hughes, JM; Dodd, NS; Cox, AP; Boyce, K; Gerwash, O; Abushahma, M; Lun, ZR; Murphy, RG; Rogan, MT; Hide, G; (2011) Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats. Parasitology, 138 (9). pp. 1117-1123. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182011000904

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Abstract

The protozoan parasite Toxoplasma gondii is prevalent worldwide and can infect a remarkably wide range of hosts despite felids being the only definitive host. As cats play a major role in transmission to secondary mammalian hosts, the interaction between cats and these hosts should be a major factor determining final prevalence in the secondary host. This study investigates the prevalence of T. gondii in a natural population of Apodemus sylvaticus collected from an area with low cat density (<2.5 cats/km(2)). A surprisingly high prevalence of 40.78% (95% CI: 34.07%-47.79%) was observed despite this. A comparable level of prevalence was observed in a previously published study using the same approaches where a prevalence of 59% (95% CI: 50.13%-67.87%) was observed in a natural population of Mus domesticus from an area with high cat density (>500 cats/km(2)). Detection of infected foetuses from pregnant dams in both populations suggests that congenital transmission may enable persistence of infection in the absence of cats. The prevalences of the related parasite, Neospora caninum were found to be low in both populations (A. sylvaticus: 3.39% (95% CI: 0.12%-6.66%); M. domesticus: 3.08% (95% CI: 0.11%-6.05%)). These results suggest that cat density may have a lower than expected effect on final prevalence in these ecosystems.

Item Type: Article
Keywords: Toxoplasma gondii, Neospora caninum, PCR, Apodemus sylvaticus, Mus, domesticus, vertical transmission, congenital transmission, vertical transmission, rattus-norvegicus, charollais sheep, mus-domesticus, united-states, wild rodents, pcr, analysis, infection, mice
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
PubMed ID: 21756421
Web of Science ID: 294613300007
URI: http://researchonline.lshtm.ac.uk/id/eprint/18754

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