Stable incidence rates of tuberculosis (TB) among human immunodeficiency virus (HIV)-negative South African gold miners during a decade of epidemic HIV-associated TB


Corbett, EL; Charalambous, S; Fielding, K; Clayton, T; Hayes, RJ; de Cock, KM; Churchyard, GJ; (2003) Stable incidence rates of tuberculosis (TB) among human immunodeficiency virus (HIV)-negative South African gold miners during a decade of epidemic HIV-associated TB. The Journal of infectious diseases, 188 (8). pp. 1156-1163. ISSN 0022-1899 DOI: https://doi.org/10.1086/378519

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Abstract

During the last decade, annual tuberculosis ( TB) case- notification rates increased 4-fold, to 14000 cases/100,000 person-years, in the study workforce, among whom prevalence of human immunodeficiency virus (HIV) was 30% in 2000. Three separate cohort studies, totalling 6454 HIV-negative participants, were combined and analyzed for time trends. Observed incidence of TB varied between 962 (1991-1994) and 1589 (1999-2000) cases/100,000 person-years (P = .17, test for trend). There was, however, a progressive increase in age, and, for each period, older age was associated with increased incidence rates of TB (P < .001). Having adjusted for age differences, there was no significant association between incidence of TB and calendar period (P = 81, test for trend). Relative to 1991-1994, multivariate-adjusted incidence-rate ratios were 0.94, for 1995-1997, 0.96, for 1998-1999, and 1.05, for 1999-2000. Preventing a secondary epidemic of TB among HIV- negative individuals may be achievable with conventional means, even in settings with a high burden of HIV-associated TB.

Item Type: Article
Keywords: active antiretroviral therapy, mycobacterial disease, pulmonary, tuberculosis, risk-factors, infection, impact, reinfection, burden, trends, kenya
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
TB Centre
Tropical Epidemiology Group
PubMed ID: 14551886
Web of Science ID: 185850100011
URI: http://researchonline.lshtm.ac.uk/id/eprint/15801

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