In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins


Camacho, MD; Phillipson, JD; Croft, SL; Yardley, V; Solis, PN; (2004) In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins. Planta medica, 70 (1). pp. 70-72. ISSN 0032-0943 DOI: https://doi.org/10.1055/s-2004-815460

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Abstract

Twenty-six pure plant-derived compounds including alkaloids, quinones, flavonoids, and coumarins, obtained from five species of Central American plants associated with traditional uses, were tested in vitro for antiprotozoal and cytotoxic activities. The quinone, 1-acetyl-benzoisochromanquinone displayed significant antiprotozoal activity against Leishmania donovani promastigotes and amastigotes, Trypanosoma cruzi amastigotes, and T. brucei brucei bloodstream form trypomastigotes, with IC50 values of 2.32, 1.98, 6.60, and 0.65 muM, respectively. The quinones benzo[g]isoquinoline-5,10-dione had an IC50 value of 4.2 muM against Plasmodium falciparum and 1-hydroxybenzoisochromanquirione an IC50 value of 3.3 muM against T. b. brucei trypomastigotes. The remaining compounds were either weakly active or inactive.

Item Type: Article
Keywords: Invitro
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
Web of Science ID: 189041000015
URI: http://researchonline.lshtm.ac.uk/id/eprint/14866

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