Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.


Bornman, L; Campbell, SJ; Fielding, K; Bah, B; Sillah, J; Gustafson, P; Manneh, K; Lisse, I; Allen, A; Sirugo, G; Sylla, A; Aaby, P; McAdam, KP; Bah-Sow, O; Bennett, S; Lienhardt, C; Hill, AV; (2004) Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. The Journal of infectious diseases, 190 (9). pp. 1631-41. ISSN 0022-1899 DOI: https://doi.org/10.1086/424462

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Abstract

Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: TB Centre
Tropical Epidemiology Group
PubMed ID: 15478069
Web of Science ID: 224303100015
URI: http://researchonline.lshtm.ac.uk/id/eprint/12522

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