Year Item Type Full Text

2025

Revisiting key assumptions about animal antibiotic use and human health from a One Health perspective. (2025) Emes, E picture_as_pdf

Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance. (2025) Holt, Kathryn E; Carey, Megan E; Chandler, Clare; Cross, James H; Dyson, Zoe A; Furnham, Nicholas; Glover, Rebecca E; Virgo, Mollie; Knight, Gwenan M

2024

A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis. (2024) Cirillo, Daniela; Anthony, Richard; Gagneux, Sebastien; Horsburgh, C Robert; Hasan, Rumina; Darboe, Saffiatou; Laniado-Laborin, Rafael; Probandari, Ari; Tukvadze, Nestani; Arcêncio, Ricardo A; Bimba, John S; Brighenti, Susanna; Chesov, Dumitru; Chiang, Chen-Yuan; Kalmambetova, Gulmira; Knight, Gwenan; Konstantynovska, Olha; Kruse, Alexandra; Lange, Christoph; Mayanja-Kizza, Harriet; McBryde, Emma; Min, Jinsoo; Sanchez-Montalva, Adrian; Sulis, Giorgia; Tsogt, Bazarragchaa; Van Der Walt, Martie; Yeboah-Manu, Dorothy; Hauser, Janika

The contribution of animal antibiotic use to antibiotic resistance in human infections: Panel evidence from Denmark. (2024) Emes, Eve; Belay, Dagim; Knight, Gwenan M

Modelling the implementation of narrow versus broader spectrum antibiotics in the empiric treatment of E. coli bacteraemia. (2024) Khurana, Mark P; Curran-Sebastian, Jacob; Bhatt, Samir; Knight, Gwenan M

Antimicrobial resistance prevalence in bloodstream infection in 29 European countries by age and sex: An observational study. (2024) Waterlow, Naomi R; Cooper, Ben S; Robotham, Julie V; Knight, Gwenan Mary

2023

Guiding pragmatic treatment choices for rifampicin-resistant tuberculosis in the absence of second-line drug susceptibility testing. (2023) Achar, Jay; Seddon, James A; Knight, Gwenan M; Dodd, Peter J; Esmail, Hanif; Hughes, Jennifer; McQuaid, C Finn

The burden and dynamics of hospital-acquired SARS-CoV-2 in England. (2023) Cooper, Ben S; Evans, Stephanie; Jafari, Yalda; Pham, Thi Mui; Mo, Yin; Lim, Cherry; Pritchard, Mark G; Pople, Diane; Hall, Victoria; Stimson, James; Eyre, David W; Read, Jonathan M; Donnelly, Christl A; Horby, Peter; Watson, Conall; Funk, Sebastian; Robotham, Julie V; Knight, Gwenan M

AHHME: A model for estimating the holistic cost-effectiveness of antimicrobial resistance interventions in food animal production. (2023) Emes, Eve T; Waage, Jeff; Knight, Gwenan M; Naylor, Nichola R

Drivers of Antibiotic Use in Semi-Intensive Poultry Farms: Evidence from a Survey in Senegal. (2023) Emes, Eve; Faye, Adiouma; Naylor, Nichola; Belay, Dagim; Ngom, Babacar; Fall, Awa Gueye; Knight, Gwen; Dione, Michel

Why local antibiotic resistance data matters - Informing empiric prescribing through local data collation, app design and engagement in Zambia. (2023) Fwoloshi, Sombo; Chola, Uchizi; Nakazwe, Ruth; Tatila, Timothy; Mateele, Tebuho; Kabaso, Mwewa; Muzyamba, Theresa; Mutwale, Ilunga; Jones, Anja St Clair; Islam, Jasmin; Chikatula, Enock; Mweemba, Aggrey; Mbewe, Wilson; Mulenga, Lloyd; Aiken, Alexander M; Anitha Menon, J; Bailey, Sarah Lou; Knight, Gwenan M

RESIST2: RESIST2 Workshop. (2023) Knight, Gwen

Quantifying patient- and hospital-level antimicrobial resistance dynamics in Staphylococcus aureus from routinely collected data. (2023) Leclerc, Quentin; Clements, Alastair; Dunn, Helen; Hatcher, James; Lindsay, Jodi A; Grandjean, Louis; Knight, Gwenan M

2022

Dehydration Tolerance in Epidemic versus Nonepidemic MRSA Demonstrated by Isothermal Microcalorimetry. (2022) Baede, Valérie O; Tavakol, Mehri; Vos, Margreet C; Knight, Gwenan M; van Wamel, Willem JB; MACOTRA study group

Quantifying the Relationship between Antibiotic Use in Food-Producing Animals and Antibiotic Resistance in Humans. (2022) Emes, David; Naylor, Nichola; Waage, Jeff; Knight, Gwenan

Maternity service reconfigurations for intrapartum and postnatal midwifery staffing shortages: modelling of low-risk births in England. (2022) Grollman, Christopher; Daniele, Marina AS; Brigante, Lia; Knight, Gwenan M; Latina, Laura; Morgan, Andrei S; Downe, Soo

Effectiveness of infection prevention and control interventions, excluding personal protective equipment, to prevent nosocomial transmission of SARS-CoV-2: a systematic review and call for action. (2021) Jafari, Yalda; Yin, Mo; Lim, Cherry; Pople, Diane; Evans, Stephanie; Stimson, James; Pham, Thi Mui; LSHTM CMMID COVID-19 working group; Read, Jonathan M; Robotham, Julie V; Cooper, Ben S; Knight, Gwenan M

RESIST2: Within-Host. (2022) Knight, Gwen

RESIST2: Transmission. (2022) Knight, Gwen

RESIST2: Policy. (2022) Knight, Gwen

RESIST2: Interventions. (2022) Knight, Gwen

Interdisciplinary investigations of phage-bacteria dynamics and generalized transduction of antimicrobial resistance in Staphylococcus aureus. (2022) Leclerc, Q

Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution. (2022) Leclerc, Quentin J; Lindsay, Jodi A; Knight, Gwenan M

Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage. (2022) Leclerc, Quentin J; Wildfire, Jacob; Gupta, Arya; Lindsay, Jodi A; Knight, Gwenan M

Quantifying the primary and secondary effects of antimicrobial resistance on surgery patients: Methods and data sources for empirical estimation in England. (2022) Naylor, Nichola R; Evans, Stephanie; Pouwels, Koen B; Troughton, Rachael; Lamagni, Theresa; Muller-Pebody, Berit; Knight, Gwenan M; Atun, Rifat; Robotham, Julie V

Impact of non-pharmaceutical interventions on SARS-CoV-2 outbreaks in English care homes: a modelling study. (2022) Rosello, Alicia; Barnard, Rosanna C; Smith, David RM; Evans, Stephanie; Grimm, Fiona; Davies, Nicholas G; Centre for Mathematical Modelling of Infectious Diseases COVID-1; Deeny, Sarah R; Knight, Gwenan M; Edmunds, W John

2021

Community transmission of multidrug-resistant tuberculosis is associated with activity space overlap in Lima, Peru. (2021) Bui, David P; Chandran, Shruthi S; Oren, Eyal; Brown, Heidi E; Harris, Robin B; Knight, Gwenan M; Grandjean, Louis

Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks. (2021) Endo, Akira; Centre for the Mathematical Modelling of Infectious Diseases COV; Leclerc, Quentin J; Knight, Gwenan M; Medley, Graham F; Atkins, Katherine E; Funk, Sebastian; Kucharski, Adam J

Antimicrobial resistance and COVID-19: Intersections and implications. (2021) Knight, Gwenan M; Glover, Rebecca E; McQuaid, C Finn; Olaru, Ioana D; Gallandat, Karin; Leclerc, Quentin J; Fuller, Naomi M; Willcocks, Sam J; Hasan, Rumina; van Kleef, Esther; Chandler, Clare Ir picture_as_pdf

The effectiveness of biosecurity interventions in reducing the transmission of bacteria from livestock to humans at the farm level: A systematic literature review. (2021) Youssef, Dina Mohamed; Wieland, Barbara; Knight, Gwenan M; Lines, Jo; Naylor, Nichola R

Understanding MRSA clonal competition within a UK hospital; the possible importance of density dependence. (2021) de Vos, Anneke S; de Vlas, Sake J; Lindsay, Jodi A; Kretzschmar, Mirjam EE; Knight, Gwenan M

2020

Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis. (2020) Coll, Francesc; Raven, Kathy E; Knight, Gwenan M; Blane, Beth; Harrison, Ewan M; Leek, Danielle; Enoch, David A; Brown, Nicholas M; Parkhill, Julian; Peacock, Sharon J

The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship. (2020) Emery, Jon C; Russell, Timothy W; Liu, Yang; Hellewell, Joel; Pearson, Carl Ab; CMMID COVID-19 Working Group; Knight, Gwenan M; Eggo, Rosalind M; Kucharski, Adam J; Funk, Sebastian; Flasche, Stefan; Houben, Rein Mgj

Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks. (2020) Endo, Akira; Centre for the Mathematical Modelling of Infectious Diseases COV; Leclerc, Quentin J; Knight, Gwenan M; Medley, Graham F; Atkins, Katherine E; Funk, Sebastian; Kucharski, Adam J

Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks. (2020) Endo, Akira; Centre for the Mathematical Modelling of Infectious Diseases COV; Leclerc, Quentin J; Knight, Gwenan M; Medley, Graham F; Atkins, Katherine E; Funk, Sebastian; Kucharski, Adam J

Potential impact of tuberculosis vaccines in China, South Africa, and India. (2020) Harris, Rebecca C; Sumner, Tom; Knight, Gwenan M; Zhang, Hui; White, Richard G picture_as_pdf

No antimicrobial resistance research agenda without tuberculosis. (2020) Knight, Gwenan M; Raviglione, Mario C; White, Richard G

What settings have been linked to SARS-CoV-2 transmission clusters? (2020) Leclerc, Quentin J; Fuller, Naomi M; Knight, Lisa E; CMMID COVID-19 Working Group; Funk, Sebastian; Knight, Gwenan M

Feasibility of informing syndrome-level empiric antibiotic recommendations using publicly available antibiotic resistance datasets. (2020) Leclerc, Quentin J; Naylor, Nichola R; Aiken, Alexander M; Coll, Francesc; Knight, Gwenan M picture_as_pdf

Ongoing challenges to understanding multidrug- and rifampicin-resistant tuberculosis in children versus adults. (2020) McQuaid, C Finn; Cohen, Ted; Dean, Anna S; Houben, Rein MGJ; Knight, Gwenan M; Zignol, Matteo; White, Richard G

The risk of multidrug- or rifampicin-resistance in males versus females with tuberculosis. (2020) McQuaid, C Finn; Horton, Katherine C; Dean, Anna S; Knight, Gwenan M; White, Richard G description

Quantitatively evaluating the cross-sectoral and One Health impact of interventions: A scoping review and case study of antimicrobial resistance. (2020) Naylor, Nichola R; Lines, Jo; Waage, Jeff; Wieland, Barbara; Knight, Gwenan M

COVID-19 length of hospital stay: a systematic review and data synthesis. (2020) Rees, Eleanor M; Nightingale, Emily S; Jafari, Yalda; Waterlow, Naomi R; Clifford, Samuel; B Pearson, Carl A; Group, Cmmid Working; Jombart, Thibaut; Procter, Simon R; Knight, Gwenan M

2019

Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study. (2018) Harris, Rebecca C; Sumner, Tom; Knight, Gwenan M; Evans, Tom; Cardenas, Vicky; Chen, Chen; White, Richard G

Mathematical modelling for antibiotic resistance control policy: do we know enough? (2019) Knight, Gwenan M; Davies, Nicholas G; Colijn, Caroline; Coll, Francesc; Donker, Tjibbe; Gifford, Danna R; Glover, Rebecca E; Jit, Mark; Klemm, Elizabeth; Lehtinen, Sonja; Lindsay, Jodi A; Lipsitch, Marc; Llewelyn, Martin J; Mateus, Ana LP; Robotham, Julie V; Sharland, Mike; Stekel, Dov; Yakob, Laith; Atkins, Katherine E

Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling. (2019) Knight, Gwenan M; McQuaid, C Finn; Dodd, Peter J; Houben, Rein MGJ

Mathematical modelling to study the horizontal transfer of antimicrobial resistance genes in bacteria: current state of the field and recommendations. (2019) Leclerc, Quentin J; Lindsay, Jodi A; Knight, Gwenan M

The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study. (2019) Naylor, Nichola R; Pouwels, Koen B; Hope, Russell; Green, Nathan; Henderson, Katherine L; Knight, Gwenan M; Atun, Rifat; Robotham, Julie V; Deeny, Sarah R

Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling. (2019) Rhodes, Sophie J; Knight, Gwenan M; Kirschner, Denise E; White, Richard G; Evans, Thomas G

2018

A Case-Control Study to Identify Community Venues Associated with Genetically-clustered, Multidrug-resistant Tuberculosis Disease in Lima, Peru. (2018) Bui, David P; Oren, Eyal; Roe, Denise J; Brown, Heidi E; Harris, Robin B; Knight, Gwenan M; Gilman, Robert H; Grandjean, Louis

The importance of cross-disciplinary research to combat antimicrobial resistance: introducing a new pop-up journal, X-AMR. (2018) Knight, Gwen; Lambert, Helen; Feil, Edward; Holmes, Mark; Lindsay, Jodi picture_as_pdf

The importance of cross-disciplinary research to combat antimicrobial resistance: introducing a new pop-up journal, X-AMR. (2018) Knight, Gwen; Lambert, Helen; Feil, Edward; Holmes, Mark; Lindsay, Jodi

Potential impact of influenza vaccine roll-out on antibiotic use in Africa. (2018) Knight, Gwenan M; Clarkson, Madeleine; de Silva, Thushan I

Quantifying where human acquisition of antibiotic resistance occurs: a mathematical modelling study. (2018) Knight, Gwenan M; Costelloe, Céire; Deeny, Sarah R; Moore, Luke SP; Hopkins, Susan; Johnson, Alan P; Robotham, Julie V; Holmes, Alison H

Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals. (2018) Knight, Gwenan M; Dyakova, Eleonora; Mookerjee, Siddharth; Davies, Frances; Brannigan, Eimear T; Otter, Jonathan A; Holmes, Alison H

The relative fitness of drug-resistant Mycobacterium tuberculosis: a modelling study of household transmission in Peru. (2018) Knight, Gwenan M; Zimic, Mirko; Funk, Sebastian; Gilman, Robert H; Friedland, Jon S; Grandjean, Louis

Estimating the burden of antimicrobial resistance: a systematic literature review. (2018) Naylor, Nichola R; Atun, Rifat; Zhu, Nina; Kulasabanathan, Kavian; Silva, Sachin; Chatterjee, Anuja; Knight, Gwenan M; Robotham, Julie V

The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data. (2018) Rhodes, SJ

Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making. (2018) Rhodes, Sophie J; Guedj, Jeremie; Fletcher, Helen A; Lindenstrøm, Thomas; Scriba, Thomas J; Evans, Thomas G; Knight, Gwenan M; White, Richard G

The modern era must end: antibiotic resistance helps us rethink medicine and farming. (2018) de Lima Hutchison, C; Knight, G; Stabler, R; Chandler, C

2017

Addressing the Unknowns of Antimicrobial Resistance: Quantifying and Mapping the Drivers of Burden. (2017) Knight, Gwenan M; Costelloe, Ceire; Murray, Kris A; Robotham, Julie V; Atun, Rifat; Holmes, Alison H

The relative fitness of drug resistant<i>Mycobacterium tuberculosis</i>: a modelling study of household transmission in Peru. (2017) Knight, Gwenan M; Zimic, Mirko; Funk, Sebastian; Gilman, Robert H; Friedland, Jon S; Grandjean, Louis

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods. (2017) Rhodes, Sophie J; Sarfas, Charlotte; Knight, Gwenan M; White, Andrew; Pathan, Ansar A; McShane, Helen; Evans, Thomas G; Fletcher, Helen; Sharpe, Sally; White, Richard G

2016

Role of pyrazinamide in the emergence of extensively drug-resistant tuberculosis: a multi-strain mathematical model. (2016) Fofana, MO; Shrestha, S; Knight, GM; Cohen, T; White, RG; Cobelens, F; Dowdy, DW description

Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis. (2016) Gomez, GB; Dowdy, DW; Bastos, ML; Zwerling, A; Sweeney, S; Foster, N; Trajman, A; Islam, MA; Kapiga, S; Sinanovic, E; Knight, GM; White, RG; Wells, WA; Cobelens, FG; Vassall, A

Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines. (2016) Harris, RC; Sumner, T; Knight, GM; White, RG

Ebola: the hidden toll of tuberculosis. (2016) Knight, Gwenan M; Houben, Rein MGJ; Lalli, Marek; White, Richard G

Methods for estimating the burden of antimicrobial resistance: a systematic literature review protocol. (2016) Naylor, Nichola R; Silva, Sachin; Kulasabanathan, Kavian; Atun, Rifat; Zhu, Nina; Knight, Gwenan M; Robotham, Julie

The TB vaccine H56+IC31 dose-response curve is peaked not saturating: Data generation for new mathematical modelling methods to inform vaccine dose decisions. (2016) Rhodes, Sophie J; Zelmer, Andrea; Knight, Gwenan M; Prabowo, Satria Arief; Stockdale, Lisa; Evans, Thomas G; Lindenstrøm, Thomas; White, Richard G; Fletcher, Helen description

Isolation demand from carbapenemase-producing Enterobacteriaceae screening strategies based on a West London hospital network. (2016) Vella, V; Moore, LSP; Robotham, JV; Davies, F; Birgand, GJC; Otter, JA; Brannigan, E; Dyakova, E; Knight, GM; Mookerjee, S; Holmes, AH

The transmission of Mycobacterium tuberculosis in high burden settings. (2016) Yates, Tom A; Khan, Palwasha Y; Knight, Gwenan M; Taylor, Jonathon G; McHugh, Timothy D; Lipman, Marc; White, Richard G; Cohen, Ted; Cobelens, Frank G; Wood, Robin; Moore, David AJ; Abubakar, Ibrahim description

2015

The complex evolution of antibiotic resistance in Mycobacterium tuberculosis. (2015) Fonseca, JD; Knight, GM; McHugh, TD

The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis. (2015) Knight, Gwenan M; Colijn, Caroline; Shrestha, Sourya; Fofana, Mariam; Cobelens, Frank; White, Richard G; Dowdy, David W; Cohen, Ted description

Bridging the gap between evidence and policy for infectious diseases: How models can aid public health decision-making. (2015) Knight, Gwenan M; Dharan, Nila J; Fox, Gregory J; Stennis, Natalie; Zwerling, Alice; Khurana, Renuka; Dowdy, David W

Tuberculosis prevention in South Africa. (2015) Knight, Gwenan M; Dodd, Peter J; Grant, Alison D; Fielding, Katherine L; Churchyard, Gavin J; White, Richard G

The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa. (2015) Knight, Gwenan M; Gomez, Gabriela B; Dodd, Peter J; Dowdy, David; Zwerling, Alice; Wells, William A; Cobelens, Frank; Vassall, Anna; White, Richard G

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status. (2015) Rhodes, Sophie J; Knight, Gwenan M; Fielding, Katherine; Scriba, Thomas J; Pathan, Ansar A; McShane, Helen; Fletcher, Helen; White, Richard G description

Within-host diversity of MRSA antimicrobial resistances. (2015) Stanczak-Mrozek, Kinga I; Manne, Anusha; Knight, Gwenan M; Gould, Katherine; Witney, Adam A; Lindsay, Jodi A

2014

Population-level impact of shorter-course regimens for tuberculosis: a model-based analysis. (2014) Fofana, Mariam O; Knight, Gwenan M; Gomez, Gabriela B; White, Richard G; Dowdy, David W

Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries. (2014) Knight, Gwenan M; Griffiths, Ulla K; Sumner, Tom; Laurence, Yoko V; Gheorghe, Adrian; Vassall, Anna; Glaziou, Philippe; White, Richard G

Drivers and trajectories of resistance to new first-line drug regimens for tuberculosis. (2014) Shrestha, Sourya; Knight, Gwenan M; Fofana, Mariam; Cohen, Ted; White, Richard G; Cobelens, Frank; Dowdy, David W

2013

Predicting the long-term impact of antiretroviral therapy scale-up on population incidence of tuberculosis. (2013) Dodd, Peter J; Knight, Gwenan M; Lawn, Stephen D; Corbett, Elizabeth L; White, Richard G

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose. (2013) Garnett, James P; Baker, Emma H; Naik, Sonam; Lindsay, Jodi A; Knight, Gwenan M; Gill, Simren; Tregoning, John S; Baines, Deborah L

Large mobile genetic elements carrying resistance genes that do not confer a fitness burden in healthcare-associated meticillin-resistant Staphylococcus aureus. (2013) Knight, Gwenan M; Budd, Emma L; Lindsay, Jodi A

2012

Shift in dominant hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) clones over time. (2012) Knight, Gwenan M; Budd, Emma L; Whitney, Laura; Thornley, Alastair; Al-Ghusein, Hasan; Planche, Timothy; Lindsay, Jodi A

Shuffling of mobile genetic elements (MGEs) in successful healthcare-associated MRSA (HA-MRSA). (2012) Lindsay, Jodi A; Knight, Gwenan M; Budd, Emma L; McCarthy, Alex J