Apnea and its possible relationship to immunization in ex-premature infants.
Cooper, Peter A;
Madhi, Shabir A;
Huebner, Robin E;
Mbelle, Nontombi;
Karim, Salim S Abdool;
Kleinschmidt, Immo;
Forrest, Bruce D;
Klugman, Keith P;
(2008)
Apnea and its possible relationship to immunization in ex-premature infants.
Vaccine, 26 (27-28).
pp. 3410-3413.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2008.04.037
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This study compared the characteristics of infants hospitalized with apnea that participated in a vaccine trial compared with two control groups which consisted of 100 infants randomly selected from the same vaccine trial and 52 consecutively born very low birth weight (VLBW) infants. A total of 23 infants were admitted with apnea of whom 19 weighed <1500 g at birth and all were born at <37 weeks gestation. More of the VLBW infants in the apnea group had neonatal neurological complications compared with the VLBW control group (p=0.005). Ten of 11 children with apnea within 72 h of immunization were possibly related to vaccination.
