The case for hypervirulence through gene deletion in Mycobacterium tuberculosis.
ten Bokum, Annemieke MC;
Movahedzadeh, Farahnaz;
Frita, Rosangela;
Bancroft, Gregory J;
Stoker, Neil G;
(2008)
The case for hypervirulence through gene deletion in Mycobacterium tuberculosis.
Trends in microbiology, 16 (9).
pp. 436-441.
ISSN 0966-842X
DOI: https://doi.org/10.1016/j.tim.2008.06.003
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Deletion of genes in a pathogen is commonly associated with a reduction in its ability to cause disease. However, some rare cases have been described in the literature whereby deletion of a gene results in an increase in virulence. Recently, there have been several reports of hypervirulence resulting from gene deletion in Mycobacterium tuberculosis. Here, we explore this phenomenon in the context of the interaction between the pathogen and the host response.
