Ibarz-Pavón, Ana Belén; Maclennan, Jenny; Andrews, Nicholas J; Gray, Stephen J; Urwin, Rachel; Clarke, Stuart C; Walker, A Mark; Evans, Meirion R; Kroll, J Simon; Neal, Keith R; +12 more... Ala'aldeen, Dlawer; Crook, Derrick W; Cann, Kathryn; Harrison, Sarah; Cunningham, Richard; Baxter, David; Kaczmarski, Edward; McCarthy, Noel D; Jolley, Keith A; Cameron, J Claire; Stuart, James M; Maiden, Martin CJ; (2011) Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation. The Journal of infectious diseases, 204 (7). pp. 1046-1053. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jir466
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Abstract
BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed. RESULTS: A total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear. CONCLUSIONS: Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction.
Item Type | Article |
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Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Research Centre | Vaccine Centre |
PubMed ID | 21881120 |
ISI | 294595900012 |
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