Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).

Julieta Coro ; Susan Little ; Vanessa Yardley ORCID logo ; Margarita Suárez ; Hortensia Rodríguez ; Nazario Martín ; Rolando Perez-Pineiro ; (2008) Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). Archiv der Pharmazie, 341 (11). pp. 708-713. ISSN 0365-6233 DOI: 10.1002/ardp.200800011
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The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
Item Type Article
Keywords Protozoocidal activity, Spermidine, 1, 3, 5-Thiadiazinane-2-thione, TRYPANOTHIONE REDUCTASE, TRYPANOSOMA-CRUZI, IN-VITRO, ANTIMICROBIAL, ACTIVITY, TRYPANOCIDAL AGENTS, CHAGAS-DISEASE, DERIVATIVES, INHIBITORS, CHEMOTHERAPY, BRUCEI
ISI 261440800005
Date Deposited 17 Oct 2011 15:42

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