Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
Papanastasiou, Ioannis;
Tsotinis, Andrew;
Zoidis, Grigoris;
Kolocouris, Nicolas;
Prathalingam, S Radhika;
Kelly, John M;
(2009)
Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
ChemMedChem, 4 (7).
pp. 1059-1062.
ISSN 1860-7179
DOI: https://doi.org/10.1002/cmdc.200900019
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.
