Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
Ioannis
Papanastasiou
;
Andrew
Tsotinis
;
Grigoris
Zoidis
;
Nicolas
Kolocouris
;
S Radhika
Prathalingam
;
John M
Kelly
;
(2009)
Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
ChemMedChem, 4 (7).
pp. 1059-1062.
ISSN 1860-7179
DOI: 10.1002/cmdc.200900019
;
(2009)
Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
ChemMedChem, 4 (7).
pp. 1059-1062.
ISSN 1860-7179
DOI: 10.1002/cmdc.200900019
Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.
Full text not available from this repository.
Downloads