Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.

Papanastasiou, I; Tsotinis, A; Zoidis, G; Kolocouris, N; Prathalingam, SR; Kelly, JMORCID logo and (2009) Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. ChemMedChem, 4 (7). pp. 1059-1062. ISSN 1860-7179 DOI: 10.1002/cmdc.200900019
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Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.
Item Type Article
ISI 267893000004
Date Deposited 17 Oct 2011 15:14

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