Population increase is exacerbating resource insecurities due to increased demand for already depleted resources. Coupled with climate change, they are the main drivers of both intra-(rural-urban and urban-urban) and inter-migration (from one country to the other). We carried out a systematic review of literature, focusing on available options to ensure water and food security, as well as improve the socio-economic environment, highlighting the drivers of migration in southern Africa. The aim was to develop informed adaptation strategies and build resilience in the advent of accelerated migration. We developed a migration conceptual framework based on the nexus between water, food and socio-economic interlinkages. Urban areas in southern Africa are under immense pressure to accommodate climate refugees from resource stressed rural areas, a situation that is impacting on agricultural production. Most urban areas are exceeding their ecological thresholds to support the built environment, causing some socio-ecological challenges. Nexus planning can inform adaptation planning on permissible migration that are aligned with regional goals such as regional integration, poverty reduction and improved livelihoods. This would also contribute to the region's achievements of the Sustainable Development Goals. Furthermore, through the identification of synergies and trade-offs, nexus planning can inform regional adaptation strategies for positively managing migration leading to sustainable outcomes.