Sustainable Development Goals (SDGs) acknowledge the inter-linkages between human wellbeing, economic prosperity, and a healthy environment and, hence, are associated with a wide range of topical issues that include the securities of water, energy and food resources, poverty eradication, economic development, climate change, health, among others. As SDGs are assessed through targets to be achieved by 2030 and monitored through measurable indicators, this study applied the nexus planning model to monitor and evaluate progress towards SDGs using South Africa as a case study. The study highlighted pathways to ensure socio-ecological sustainability and environmental health by establishing the connectivity between SDGs and nexus approaches. The linkages between SDGs and nexus planning facilitated the sustainable management of resources in an integrated manner. They addressed the cross-sectoral synergies, value-addition, and trade-offs within interlinked sectors. The connectedness of current challenges facing humankind (climate change, rapid urbanisation, migration, and the emergence of novel infectious diseases) require transformative approaches that address these cross-cutting challenges holistically. Managing the intricate relationships between distinct but interconnected sectors through nexus planning has provided decision support tools to formulate coherent strategies that drive resilience and sustainability. The established linkages between nexus planning and SDGs have strengthened cross-sectoral collaboration and unpacked measures for cooperative governance and management through evidence-based interventions. As food production, water provision, and energy accessibility are the major socio-economic and environmental issues currently attracting global attention; the methodology promotes attaining sustainability by 2030.