A patatin-like phospholipase is important for mitochondrial function in malaria parasites.

Pietsch, EORCID logo; Ramaprasad, AORCID logo; Bielfeld, S; Wohlfarter, YORCID logo; Maco, BORCID logo; Niedermüller, K; Wilcke, LORCID logo; Kloehn, JORCID logo; Keller, MAORCID logo; Soldati-Favre, DORCID logo; +3 more...Blackman, MJORCID logo; Gilberger, TORCID logo; Burda, PORCID logo and (2023) A patatin-like phospholipase is important for mitochondrial function in malaria parasites. mBio, 14 (6). e0171823-. ISSN 2150-7511 DOI: 10.1128/mbio.01718-23
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For their proliferation within red blood cells, malaria parasites depend on a functional electron transport chain (ETC) within their mitochondrion, which is the target of several antimalarial drugs. Here, we have used gene disruption to identify a patatin-like phospholipase, PfPNPLA2, as important for parasite replication and mitochondrial function in Plasmodium falciparum. Parasites lacking PfPNPLA2 show defects in their ETC and become hypersensitive to mitochondrion-targeting drugs. Furthermore, PfPNPLA2-deficient parasites show differences in the composition of their cardiolipins, a unique class of phospholipids with key roles in mitochondrial functions. Finally, we demonstrate that parasites devoid of PfPNPLA2 have a defect in gametocyte maturation, underlining the importance of a functional ETC for parasite transmission to the mosquito vector.


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