Pinedo-Cancino, Viviana; Arista, Katty M; Valle-Campos, Andree; Saavedra-Langer, Rafael; Roca, Cristian; Ramos-Rincón, José-Manuel; Calderón, Maritza; Branch, Oralee H; (2022) Perfiles hematológicos en pacientes infectados con malaria en un área endémica del Perú [Hematological profiles of malaria-infected patients in an endemic area of Peru]. Revista peruana de medicina experimental y salud publica, 39 (3). pp. 336-344. ISSN 1726-4634 https://www.scielosp.org/article/rpmesp/2022.v39n3...
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Abstract
OBJECTIVES.: To evaluate the variation of hematological profiles of patients infected with uncomplicated Plasmodium vivax (Pv) and P. falciparum (Pf) malaria before, during and after treatment in a population of the Loreto region. MATERIALS AND METHODS.: This study was conducted between 2010 and 2012, in Zungarococha (Iquitos). The 425 participants had three visits (visit 1-day 0-before treatment, visit 2-day 7-during treatment, visit 3-day 28-after treatment), complete blood count, microscopic and molecular diagnosis (PCR). RESULTS.: At the first visit, 93 (21.9%) participants were found positive for Pv and 34 (8.0%) for Pf. All positives showed a reduction in hematocrit, white blood cell count (WBC), ablated and segmented neutrophils, eosinophils and platelets (p<0.001) compared to the negative group. A higher percentage of ablated neutrophils was found in Pf and segmented neutrophils in Pv compared to the negative group. Variations in hematological profiles were observed after treatment for both species; ablated neutrophils decreased, platelets increased, eosinophils increased at day 7 and declined at day 28, hematocrit and segmented neutrophils decreased at day 7 and normalized at day 28. Interspecies differences over time showed a bigger daily decrease in ablated neutrophils in Pv-infected when compared to Pf. CONCLUSIONS.: The hematological profile in uncomplicated malaria-positive patients varies over time during and after treatment. These are indicators of disease progression and help in the therapeutic surveillance of Plasmodium-infected patients.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & Dynamics (2023-) |
PubMed ID | 36478167 |
Elements ID | 212483 |
Official URL | https://www.scielosp.org/article/rpmesp/2022.v39n3... |
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