CHALLENGES IN ESTIMATING THE EFFECTIVENESS OF 2 DOSES OF COVID-19 VACCINE BEYOND 6 MONTHS IN ENGLAND.

Horne, Elsie MF; Hulme, William J; Keogh, Ruth H; Palmer, Tom M; Williamson, Elizabeth J; Parker, Edward PK; Walker, Venexia M; Knight, Rochelle; Wei, Yinghui; Taylor, Kurt; +8 more... Fisher, Louis; Morley, Jessica; Mehrkar, Amir; Dillingham, Iain; Bacon, Sebastian; Goldacre, Ben; Sterne, Jonathan AC; OpenSAFELY Collaborative, For The; (2023) CHALLENGES IN ESTIMATING THE EFFECTIVENESS OF 2 DOSES OF COVID-19 VACCINE BEYOND 6 MONTHS IN ENGLAND. American journal of epidemiology, 193 (1). pp. 227-231. ISSN 0002-9262 DOI: https://doi.org/10.1093/aje/kwad179

Abstract

Understanding how effectiveness of COVID-19 vaccines changes over time and in response to new SARSCoV-2 variants is crucial to scheduling subsequent doses. A previous study quantified vaccine effectiveness (VE) over six consecutive 4-week periods from 2 to 26 weeks after second dose (1). Waning of hazard ratios (HRs) comparing vaccinated with unvaccinated individuals was approximately log-linear over time, and consistent across COVID-19-related outcomes and risk-based subgroups. To investigate waning beyond 26 weeks and in the omicron era, we extended follow-up to the earliest of 50 weeks after second dose or 31 March 2022.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID	37656609
Elements ID	208678
Official URL	http://dx.doi.org/10.1093/aje/kwad179