Nasrin, Dilruba; Liang, Yuanyuan; Powell, Helen; Casanova, Ines Gonzalez; Sow, Samba O; Hossain, M Jahangir; Omore, Richard; Sanogo, Doh; Tamboura, Boubou; Zaman, Syed MA; +13 more... Antonio, Martin; Jones, Joquina Chiquita M; Awuor, Alex O; Kasumba, Irene N; Ochieng, John B; Badji, Henry; Verani, Jennifer R; Widdowson, Marc-Alain; Roose, Anna; Jamka, Leslie P; Tennant, Sharon M; Ramakrishnan, Usha; Kotloff, Karen L; (2023) Moderate-to-Severe Diarrhea and Stunting Among Children Younger Than 5 Years: Findings From the Vaccine Impact on Diarrhea in Africa (VIDA) Study. Clinical Infectious Diseases, 76 (76 Sup). S41-S48. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/ciac945
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Abstract
BACKGROUND: Stunting affects >20% of children <5 years old worldwide and disproportionately impacts underserved communities. The Vaccine Impact on Diarrhea in Africa (VIDA) Study examined the association between an episode of moderate-to-severe diarrhea (MSD) and the risk of subsequent stunting in children <5 years living in 3 sub-Saharan African countries. METHODS: In this prospective, matched, case-control study among children <5 years, data were collected over 36 months from 2 groups. "Children with MSD" visited a health center within 7 days of illness onset experiencing ≥3 loose stools/day plus sunken eyes, poor skin turgor, dysentery, intravenous rehydration, or hospitalization. "Children without MSD" were enrolled from the community within 14 days of the index MSD child; they were diarrhea-free during the previous 7 days and were matched to the index case by age, sex, and residence. Using generalized linear mixed-effects models, we estimated the effect of an MSD episode on odds of being stunted, defined as height-for-age z-scores <-2, at a follow-up visit 2-3 months post-enrollment. RESULTS: The proportion of stunting at enrollment was similar when 4603 children with MSD and 5976 children without MSD were compared (21.8% vs 21.3%; P = .504). Among children not stunted at enrollment, those with MSD had 30% higher odds of being stunted at follow-up than children without MSD after controlling for age, sex, study site, and socioeconomic status (adjusted OR: 1.30; 95% CI: 1.05-1.62: P = .018). CONCLUSIONS: Children <5 years in sub-Saharan Africa without stunting experienced an increased likelihood of stunting during 2-3 months following an episode of MSD. Strategies for control of early childhood diarrhea should be integrated into programs intended to reduce childhood stunting.
Item Type | Article |
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Faculty and Department |
MRC Gambia > GM-Gambia Clinical Services/Comms MRC Gambia > GM-Vaccinology Theme |
PubMed ID | 37074430 |
Elements ID | 205046 |
Official URL | http://dx.doi.org/10.1093/cid/ciac945 |
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