Abstract On 23 July 2022, the World Health Organization reported monkeypox cases in over 75 countries and, as a result, declared the virus a Public Health Emergency of International Concern (PHEIC). Despite Africa being the centre of the zoonotic disease evolution, its healthcare systems have not provided optimum attention to the problem. The African healthcare system is under the threat of a repeat of the situation that transpired during the COVID‐19 pandemonium if stringent measures are not implemented immediately. Lessons learned from the COVID‐19 pandemic should inform emergency preparedness and response from African countries. Concerted and sustainable efforts can be achieved by reviewing and redesigning strategic preparedness plans for testing and vaccination as in previous pandemics. Africa needs to drive this response with collaboration and a united response, and with the use of strategic communication and a sense of urgency. Africa should prioritise access to available vaccines and invest in systems development for local vaccine production. In this article, we argue that monkeypox virus has serious public health implications in Africa and the region.