Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.

Molloy, Síle F; Ross, Brad; Kanyama, Cecilia; Mfinanga, Sayoki; Lesikari, Sokoine; Heyderman, Robert S; Kalata, Newton; Ellis, Jayne; Kouanfack, Charles; Chanda, Duncan; +15 more... Temfack, Elvis; Lakhi, Shabir; Moodley, Anand; Chan, Adrienne K; van Oosterhout, Joep J; Mapoure, Yacouba; Mwaba, Peter; Lalloo, David G; Wang, Duolao; Lortholary, Olivier; Jaffar, Shabbar; Hosseinipour, Mina C; Loyse, Angela; Harrison, Thomas S; Bicanic, Tihana; (2021) Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. Open forum infectious diseases, 8 (4). ofab066. ISSN 2328-8957 DOI: https://doi.org/10.1093/ofid/ofab066

Abstract

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID	33937434
Elements ID	201924
Official URL	http://dx.doi.org/10.1093/ofid/ofab066