Nigeria has much popularity for several undesirable statistics, like the degree of endemicity of several illnesses and the prevalence of disease predisposing factors such as poverty. The increased incidence and prevalence of zoonotic diseases, coupled with the ongoing issue of Antimicrobial Resistance (AMR), has demanded a new approach to addressing disease conditions. One Health speculates that disease needs to be managed with a balanced view of how it connects humans, animals and the environment. It will mean application of skills from different professionals in managing, treating and preventing diseases. Nigeria has already begun implementing One Health; this process needs to be addressed as it faces a number of challenges. These can be surmounted by creating and implementing effective policies, national One Health Awareness Campaigns and increasing the unity and development in its health care delivery system.