Calvert, Clara; Carruthers, Jade; Denny, Cheryl; Donaghy, Jack; Hillman, Sam; Hopcroft, Lisa EM; Hopkins, Leanne; Goulding, Anna; Lindsay, Laura; McLaughlin, Terry; +18 more... Moore, Emily; Pan, Jiafeng; Taylor, Bob; Almaghrabi, Fatima; Auyeung, Bonnie; Bhaskaran, Krishnan; Gibbons, Cheryl L; Katikireddi, Srinivasa Vittal; McCowan, Colin; Murray, Josie; O'Leary, Maureen; Ritchie, Lewis D; Shah, Syed Ahmar; Simpson, Colin R; Robertson, Chris; Sheikh, Aziz; Stock, Sarah J; Wood, Rachael; (2022) A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection. Nature communications, 13 (1). 6124-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-022-33937-y
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Abstract
Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
Item Type | Article |
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Faculty and Department |
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Research Centre |
Covid-19 Research Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 36253471 |
Elements ID | 195820 |
Official URL | http://dx.doi.org/10.1038/s41467-022-33937-y |
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Licence: Creative Commons: Attribution 4.0
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