Charani, Esmita; McKee, Martin; Ahmad, Raheelah; Balasegaram, Manica; Bonaconsa, Candice; Merrett, Gemma Buckland; Busse, Reinhard; Carter, Vanessa; Castro-Sanchez, Enrique; Franklin, Bryony D; +18 more... Georgiou, Pantelis; Hill-Cawthorne, Kerri; Hope, William; Imanaka, Yuichi; Kambugu, Andrew; Leather, Andrew Jm; Mbamalu, Oluchi; McLeod, M; Mendelson, Marc; Mpundu, Mirfin; Rawson, Timothy M; Ricciardi, Walter; Rodriguez-Manzano, Jesus; Singh, Sanjeev; Tsioutis, Constantinos; Uchea, Chibuzor; Zhu, Nina; Holmes, Alison H; (2021) Optimising antimicrobial use in humans - review of current evidence and an interdisciplinary consensus on key priorities for research. The Lancet regional health. Europe, 7. 100161-. ISSN 2666-7762 DOI: https://doi.org/10.1016/j.lanepe.2021.100161
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Abstract
Addressing the silent pandemic of antimicrobial resistance (AMR) is a focus of the 2021 G7 meeting. A major driver of AMR and poor clinical outcomes is suboptimal antimicrobial use. Current research in AMR is inequitably focused on new drug development. To achieve antimicrobial security we need to balance AMR research efforts between development of new agents and strategies to preserve the efficacy and maximise effectiveness of existing agents. Combining a review of current evidence and multistage engagement with diverse international stakeholders (including those in healthcare, public health, research, patient advocacy and policy) we identified research priorities for optimising antimicrobial use in humans across four broad themes: policy and strategic planning; medicines management and prescribing systems; technology to optimise prescribing; and context, culture and behaviours. Sustainable progress depends on: developing economic and contextually appropriate interventions; facilitating better use of data and prescribing systems across healthcare settings; supporting appropriate and scalable technological innovation. Implementing this strategy for AMR research on the optimisation of antimicrobial use in humans could contribute to equitable global health security.
Item Type | Article |
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Faculty and Department | Faculty of Public Health and Policy > Dept of Health Services Research and Policy |
PubMed ID | 34557847 |
Elements ID | 165472 |
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Filename: Optimising antimicrobial use in humans - review of current evidence and an interdisciplinary consensus on key priorities for.pdf
Licence: Creative Commons: Attribution 3.0
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