A systematic review and network meta-analyses to assess the effectiveness of HIV self-testing distribution strategies.

Eshun-Wilson, Ingrid; Jamil, Muhammad S; T Charles, Witzel; Glidden, Dave V; Cheryl, Johnson; Noelle, Trouneau; Ford, Nathan; McGee, Kathleen; Chris, Kemp; Stefan, Baral; +2 more... Schwartz, Sheree; Elvin, Geng H; (2021) A systematic review and network meta-analyses to assess the effectiveness of HIV self-testing distribution strategies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73 (4). e1018-e1028. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/ciab029

Abstract

BACKGROUND: We conducted a systematic review and network meta-analysis to identify which HIV self-testing (HIVST) distribution strategies are most effective. METHODS: We abstracted data from randomized controlled trials and observational studies published between June 4, 2006 and June 4, 2019. RESULTS: We included 33 studies, yielding six HIVST distribution strategies. All distribution strategies increased testing uptake compared to standard testing: in sub-Saharan Africa, partner HIVST distribution ranked highest (78% probability); in North America, Asia and the Pacific regions, web-based distribution ranked highest (93% probability), and facility based distribution ranked second in all settings. Across HIVST distribution strategies HIV positivity and linkage was similar to standard testing. CONCLUSION: A range of HIVST distribution strategies are effective in increasing HIV testing. HIVST distribution by sexual partners, web-based distribution, as well as health facility distribution strategies should be considered for implementation to expand the reach of HIV testing services.