Guidelines for performing Mendelian randomization investigations: update for summer 2023.

Burgess, Stephen; Davey Smith, George; Davies, Neil M; Dudbridge, Frank; Gill, Dipender; Glymour, M Maria; Hartwig, Fernando P; Kutalik, Zoltán; Holmes, Michael V; Minelli, Cosetta; +4 more... Morrison, Jean V; Pan, Wei; Relton, Caroline L; Theodoratou, Evropi; (2019) Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Research, 4. 186-. DOI: https://doi.org/10.12688/wellcomeopenres.15555.3

Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology Academic Services & Administration > Directorate
PubMed ID	32760811
Elements ID	150839