Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics.
Tozetto-Mendoza, Tania Regina;
Avelino-Silva, Vivian Iida;
Fonseca, Silvia;
Claro, Ingra Morales;
Paula, Anderson Vicente de;
Levin, Anna Sara;
Sabino, Ester Cerdeira;
Mendes-Correa, Maria Cassia;
Figueiredo, Walter Manso;
Felix, Alvina Clara;
+9 more...Souza, Nathalia C Santiago;
Costa, Angela Aparecida;
Inenami, Marta;
Silva, Rosangela M Gasparetto da;
Levi, José Eduardo;
Romano, Camila Malta;
Paranhos-Baccalà, Glaucia;
Segurado, Aluisio Cotrim;
Mayaud, Philippe;
(2019)
Zika virus infection among symptomatic patients from two healthcare centers in Sao Paulo State, Brazil: prevalence, clinical characteristics, viral detection in body fluids and serodynamics.
Revista do Instituto de Medicina Tropical de Sao Paulo, 61.
e19-.
ISSN 0036-4665
DOI: https://doi.org/10.1590/S1678-9946201961019
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Zika virus (ZIKV) clinical presentation and frequency/duration of shedding need further clarification. Symptomatic ZIKV-infected individuals identified in two hospitals in Sao Paulo State, Brazil, were investigated regarding clinical characteristics, shedding in body fluids, and serodynamics. Ninety-four of 235 symptomatic patients (Site A: 58%; Site B: 16%) had Real-Time PCR-confirmed ZIKV infection; fever, headache and gastrointestinal symptoms were less frequent, and rash was more frequent compared to ZIKV-negative patients. Real-Time PCR in serum had worse performance compared to plasma, while urine had the highest sensitivity. Shedding in genital fluids and saliva was rare. IgM positivity was the highest <14 days after the symptoms onset (86%), decreasing >28 days (24%); IgG positivity increased >14 days (96%) remaining positive in 94% of patients >28 days. ZIKV prevalence varied importantly in two neighboring cities during the same transmission season. Urine Real-Time PCR can improve diagnostic sensitivity; serum testing is less useful. Accurate serological tests are needed to improve diagnosis and surveillance.