FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants.
Parker, Edward PK;
Whitfield, Helena;
Baskar, Chudarkodi;
Giri, Sidhartha;
John, Jacob;
Grassly, Nicholas C;
Kang, Gagandeep;
Praharaj, Ira;
(2019)
FUT2 Secretor Status Is Not Associated With Oral Poliovirus Vaccine Immunogenicity in South Indian Infants.
The Journal of Infectious Diseases, 219 (4).
pp. 578-581.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiy553
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FUT2 determines whether histo-blood group antigens are secreted at mucosal surfaces. Secretor status influences susceptibility to enteric viruses, potentially including oral poliovirus vaccine (OPV). We performed a nested case-control study to determine the association between FUT2 genotype (single-nucleotide polymorphisms G428A, C302T, and A385T) and seroconversion among Indian infants who received a single dose of monovalent type 3 OPV. Secretor prevalence was 75% (89 of 118) in infants who seroconverted and 80% (97 of 122) in infants who did not seroconvert (odds ratio, 0.79; 95% confidence interval, .43-1.45). Our findings suggest that FUT2 genotype is not a key determinant of variation in OPV immunogenicity.
