Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.

Porco, Travis C; Hart, John; Arzika, Ahmed M; Weaver, Jerusha; Kalua, Khumbo; Mrango, Zakayo; Cotter, Sun Y; Stoller, Nicole E; O'Brien, Kieran S; Fry, Dionna M; +7 more... Vanderschelden, Benjamin; Oldenburg, Catherine E; West, Sheila K; Bailey, Robin L; Keenan, Jeremy D; Lietman, Thomas M; Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Rési; (2019) Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68 (12). pp. 2114-2116. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/ciy973

Abstract

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.