Progress in interferon-gamma release assay development and applications: an unfolding story of translational research.
Lalvani, Ajit;
Whitworth, Hilary S;
(2019)
Progress in interferon-gamma release assay development and applications: an unfolding story of translational research.
Annals of translational medicine, 7 (Suppl).
S128-.
ISSN 2305-5839
DOI: https://doi.org/10.21037/atm.2019.05.76
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The introduction of blood-based tests for M. tuberculosis (Mtb) infection approximately 15 years ago was a turning point for diagnosis of latent tuberculosis (TB). Interferon-gamma release assays (IGRAs), which measure Mtb antigen-specific T cell responses, include the ELISpot-based T-SPOT.TB (Oxford Immunotec, Abingdon, UK) and the ELISA-based QuantiFERON Gold In-Tube (QFT-GIT; Qiagen, Hilden, Germany).