Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

Biagini, Giancarlo A; Fisher, Nicholas; Shone, Alison E; Mubaraki, Murad A; Srivastava, Abhishek; Hill, Alisdair; Antoine, Thomas; Warman, Ashley J; Davies, Jill; Pidathala, Chandrakala; +22 more... Amewu, Richard K; Leung, Suet C; Sharma, Raman; Gibbons, Peter; Hong, David W; Pacorel, Bénédicte; Lawrenson, Alexandre S; Charoensutthivarakul, Sitthivut; Taylor, Lee; Berger, Olivier; Mbekeani, Alison; Stocks, Paul A; Nixon, Gemma L; Chadwick, James; Hemingway, Janet; Delves, Michael J; Sinden, Robert E; Zeeman, Anne-Marie; Kocken, Clemens HM; Berry, Neil G; O'Neill, Paul M; Ward, Stephen A; (2012) Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proceedings of the National Academy of Sciences of the United States of America, 109 (21). pp. 8298-8303. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1205651109

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