Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.

Baragaña, Beatriz; Norcross, Neil R; Wilson, Caroline; Porzelle, Achim; Hallyburton, Irene; Grimaldi, Raffaella; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Stojanovski, Laste; +17 more... Simeons, Frederick RC; Wyatt, Paul G; Delves, Michael J; Meister, Stephan; Duffy, Sandra; Avery, Vicky M; Winzeler, Elizabeth A; Sinden, Robert E; Wittlin, Sergio; Frearson, Julie A; Gray, David W; Fairlamb, Alan H; Waterson, David; Campbell, Simon F; Willis, Paul; Read, Kevin D; Gilbert, Ian H; (2016) Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of medicinal chemistry, 59 (21). pp. 9672-9685. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.6b00723

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