Babu, GR; Murthy, GVS; Ana, Y; Patel, P; Deepa, R; Neelon, SEB; Kinra, S; Reddy, KS; (2017) Association of obesity with hypertension and type 2 diabetes mellitus in India: A meta-analysis of observational studies. World journal of diabetes, 9 (1). pp. 40-52. ISSN 1948-9358 DOI: https://doi.org/10.4239/wjd.v9.i1.40
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Abstract
To perform a meta-analysis of the association of obesity with hypertension and type 2 diabetes mellitus (T2DM) in India among adults. To conduct meta-analysis, we performed comprehensive, electronic literature search in the PubMed, CINAHL Plus, and Google Scholar. We restricted the analysis to studies with documentation of some measure of obesity namely; body mass index, waist-hip ratio, waist circumference and diagnosis of hypertension or diagnosis of T2DM. By obtaining summary estimates of all included studies, the meta-analysis was performed using both RevMan version 5 and "metan" command STATA version 11. Heterogeneity was measured by I2 statistic. Funnel plot analysis has been done to assess the study publication bias. Of the 956 studies screened, 18 met the eligibility criteria. The pooled odds ratio between obesity and hypertension was 3.82 (95%CI: 3.39 to 4.25). The heterogeneity around this estimate (I2 statistic) was 0%, indicating low variability. The pooled odds ratio from the included studies showed a statistically significant association between obesity and T2DM (OR = 1.14, 95%CI: 1.04 to 1.24) with a high degree of variability. Despite methodological differences, obesity showed significant, potentially plausible association with hypertension and T2DM in studies conducted in India. Being a modifiable risk factor, our study informs setting policy priority and intervention efforts to prevent debilitating complications.
Item Type | Article |
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Faculty and Department |
Faculty of Public Health and Policy > Dept of Social and Environmental Health Research Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Research Centre | International Centre for Eye Health |
PubMed ID | 29359028 |
ISI | 422851500004 |
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