Effect of early intervention on 5-year outcome in non-affective psychosis.
Gafoor, Rafael;
Nitsch, Dorothea;
McCrone, Paul;
Craig, Tom KJ;
Garety, Philippa A;
Power, Paddy;
McGuire, Philip;
(2010)
Effect of early intervention on 5-year outcome in non-affective psychosis.
The British journal of psychiatry, 196 (5).
pp. 372-376.
ISSN 0007-1250
DOI: https://doi.org/10.1192/bjp.bp.109.066050
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BACKGROUND: Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure. AIMS: To assess the long-term effect of early intervention in psychosis. METHOD: Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874). Outcome after 5 years was assessed by case-note review. RESULTS: There were no significant differences in the admission rate (coefficient 0.096, 95% CI -0.550 to 0.742, P = 0.770) or the mean number of bed days (coefficient 6.344, 95% CI -46 to 58.7, P = 0.810). CONCLUSIONS: These findings that specialist intervention did not markedly improved outcome at 5 years accord with those from a larger OPUS study. The sample size of this study was small and these results should be generalised with caution. More research is needed.
