pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Sutherland, CJ
; Lansdell, P; Sanders, M; Muwanguzi, J; van Schalkwyk, DA; Kaur, H; Nolder, D; Tucker, J; Bennett, HM; Otto, TD; +5 more...Berriman, M; Patel, TA; Lynn, R; Gkrania-Klotsas, E; Chiodini, PL and
(2016)
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Antimicrobial agents and chemotherapy, 61 (3).
ISSN 0066-4804
DOI: 10.1128/AAC.02382-16
; Lansdell, P; Sanders, M; Muwanguzi, J; van Schalkwyk, DA; Kaur, H; Nolder, D; Tucker, J; Bennett, HM; Otto, TD; +5 more...Berriman, M; Patel, TA; Lynn, R; Gkrania-Klotsas, E; Chiodini, PL and
(2016)
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Antimicrobial agents and chemotherapy, 61 (3).
ISSN 0066-4804
DOI: 10.1128/AAC.02382-16
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
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