A comparison of the change in clinical severity scale score and a retrospective physician assessment of neurological outcome in individuals with leprosy associated nerve function impairment after treatment with corticosteroids.
Walker, Stephen L;
Nicholls, Peter G;
Dhakal, Sushmita;
Hawksworth, Rachel A;
Macdonald, Murdo;
Mahat, Kishori;
Ruchal, Shudan;
Hamal, Sushma;
Hagge, Deanna A;
Neupane, Kapid Dev;
+1 more...Lockwood, Diana NJ;
(2012)
A comparison of the change in clinical severity scale score and a retrospective physician assessment of neurological outcome in individuals with leprosy associated nerve function impairment after treatment with corticosteroids.
Leprosy review, 83 (2).
pp. 154-163.
ISSN 0305-7518
https://researchonline.lshtm.ac.uk/id/eprint/292298
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OBJECTIVES: To determine whether the measured change in score of a validated clinical severity scale reflected physician assessed improvement in individuals who had received corticosteroid therapy for leprosy associated nerve damage. DESIGN: Patients with nerve function impairment who participated in a randomised controlled trial of corticosteroids were classified into two groups using a retrospectively determined physician assessment of improvement. One group consisted of patients who had recovered or improved the other of patients who were unchanged or had deteriorated. The change in the clinical severity scale scores of these two groups was compared. RESULTS: The change in the clinical severity scale scores of the 34 eligible individuals in the two groups were significantly different (P = 0.003). Individuals in the group who recovered or improved had a greater change in severity score than those whose nerve function was unchanged or deteriorated. CONCLUSION: The scale for measuring the severity of leprosy Type 1 reactions (T1Rs) and/or nerve function impairment reflects the clinical improvement of individuals with leprosy associated nerve damage.
