To promote and sustain excellent vaccination coverage, while preserving the key core values of ethics, truth, transparency, and trust, the vaccine community should adopt modern digital communication strategies. This article summarizes our views - as experts in multidisciplinary field of vaccinology, which were presented at a satellite symposium held at the 33 European Society of Paediatric Infectious Disease (ESPID) conference in Leipzig, Germany, in May 2015. This article aims to suggest and recommend strategies to promote vaccination awareness and highlight proactive measures for building, maintaining, and enhancing trust in vaccination through innovative communication and evidence-based interaction with the end-user. We believe that converting the results of vaccine research into a successful vaccination program, and replacing misinformation with evidence-based communication, will require a multidisciplinary approach that embraces modern digital and tailored applications to reach all populations.