Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis.

Matakidou, A; El Galta, R; Rudd, MF; Webb, EL; Bridle, H; Eisen, T; Houlston, RS; (2007) Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis. British journal of cancer, 96 (12). pp. 1904-1907. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6603816

Abstract

The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-)
PubMed ID	17519899
ISI	247218100019
Related URLs	OA Location