CATH: comprehensive structural and functional annotations for genome sequences.

Ian Sillitoe ; Tony E Lewis ; Alison Cuff ; Sayoni Das ; Paul Ashford ; Natalie L Dawson ; Nicholas Furnham ORCID logo ; Roman A Laskowski ; David Lee ; Jonathan G Lees ; +4 more... Sonja Lehtinen ; Romain A Studer ; Janet Thornton ; Christine A Orengo ; (2014) CATH: comprehensive structural and functional annotations for genome sequences. Nucleic acids research, 43 (Databa). D376-D381. ISSN 0305-1048 DOI: 10.1093/nar/gku947
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The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.


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