Drug sensitivity of Leishmania species: some unresolved problems.

Simon L Croft ORCID logo ; Vanessa Yardley ORCID logo ; Howard Kendrick ; (2002) Drug sensitivity of Leishmania species: some unresolved problems. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 Sup (SUPPL.). S127-S129. ISSN 0035-9203 DOI: 10.1016/s0035-9203(02)90063-5
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Leishmania species show a significant variation in their sensitivity to established and experimental drugs. Molecular techniques to identify species in clinical infections rapidly could be used to guide treatment. Molecular markers are required to detect and monitor acquired resistance to antimonial drugs. Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs.
Item Type Article
Keywords Animal, Antiprotozoal Agents/*pharmacology, Drug Evaluation, Preclinical/methods, Drug Resistance, Human, Leishmania/classification/*drug effects, Parasitic Sensitivity Tests, Support, Non-U.S. Gov't, Animal, Antiprotozoal Agents, pharmacology, Drug Evaluation, Preclinical, methods, Drug Resistance, Human, Leishmania, classification, drug effects, Parasitic Sensitivity Tests, Support, Non-U.S. Gov't
Date Deposited 17 Oct 2011 22:03

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