Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults.

Martin OC Ota ; Johan Vekemans ; Susanna E Schlegel-Haueter ; Katherine Fielding ORCID logo ; Hilton Whittle ; Paul Henri Lambert ; Keith PWJ McAdam ; Claire Anne Siegrist ; Arnaud Marchant ; (2004) Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. Vaccine, 22 (3-4). pp. 511-519. ISSN 0264-410X DOI: 10.1016/j.vaccine.2003.07.020
Copy

New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.

Full text not available from this repository.

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads