Artemisone--a highly active antimalarial drug of the artemisinin class.
Richard K
Haynes
;
Burkhard
Fugmann
;
Jörg
Stetter
;
Karl
Rieckmann
;
Hans-Dietrich
Heilmann
;
Ho-Wai
Chan
;
Man-Ki
Cheung
;
Wai-Lun
Lam
;
Ho-Ning
Wong
;
Simon L
Croft
;
+16 more...
Livia
Vivas
;
Lauren
Rattray
;
Lindsay
Stewart
;
Wallace
Peters
;
Brian L
Robinson
;
Michael D
Edstein
;
Barbara
Kotecka
;
Dennis E
Kyle
;
Bernhard
Beckermann
;
Michael
Gerisch
;
Martin
Radtke
;
Gabriele
Schmuck
;
Wolfram
Steinke
;
Ute
Wollborn
;
Karl
Schmeer
;
Axel
Römer
;
(2006)
Artemisone--a highly active antimalarial drug of the artemisinin class.
Angewandte Chemie (International ed in English), 45 (13).
pp. 2082-2088.
ISSN 1433-7851
DOI: 10.1002/anie.200503071
;
+16 more...
Livia
Vivas
;
Lauren
Rattray
;
Lindsay
Stewart
;
Wallace
Peters
;
Brian L
Robinson
;
Michael D
Edstein
;
Barbara
Kotecka
;
Dennis E
Kyle
;
Bernhard
Beckermann
;
Michael
Gerisch
;
Martin
Radtke
;
Gabriele
Schmuck
;
Wolfram
Steinke
;
Ute
Wollborn
;
Karl
Schmeer
;
Axel
Römer
;
(2006)
Artemisone--a highly active antimalarial drug of the artemisinin class.
Angewandte Chemie (International ed in English), 45 (13).
pp. 2082-2088.
ISSN 1433-7851
DOI: 10.1002/anie.200503071
Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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