Artemisone--a highly active antimalarial drug of the artemisinin class.
Haynes, Richard K; Fugmann, Burkhard; Stetter, Jörg; Rieckmann, Karl; Heilmann, Hans-Dietrich; Chan, Ho-Wai; Cheung, Man-Ki; Lam, Wai-Lun; Wong, Ho-Ning; Croft, Simon L
; +16 more...Vivas, Livia; Rattray, Lauren; Stewart, Lindsay; Peters, Wallace; Robinson, Brian L; Edstein, Michael D; Kotecka, Barbara; Kyle, Dennis E; Beckermann, Bernhard; Gerisch, Michael; Radtke, Martin; Schmuck, Gabriele; Steinke, Wolfram; Wollborn, Ute; Schmeer, Karl; and Römer, Axel
(2006)
Artemisone--a highly active antimalarial drug of the artemisinin class.
Angewandte Chemie (International ed in English), 45 (13).
pp. 2082-2088.
ISSN 1433-7851
DOI: 10.1002/anie.200503071
; +16 more...Vivas, Livia; Rattray, Lauren; Stewart, Lindsay; Peters, Wallace; Robinson, Brian L; Edstein, Michael D; Kotecka, Barbara; Kyle, Dennis E; Beckermann, Bernhard; Gerisch, Michael; Radtke, Martin; Schmuck, Gabriele; Steinke, Wolfram; Wollborn, Ute; Schmeer, Karl; and Römer, Axel
(2006)
Artemisone--a highly active antimalarial drug of the artemisinin class.
Angewandte Chemie (International ed in English), 45 (13).
pp. 2082-2088.
ISSN 1433-7851
DOI: 10.1002/anie.200503071
Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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