A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.
Cooke, Graham S;
Tosh, Kerrie;
Ramaley, Patricia A;
Kaleebu, Pontiano;
Zhuang, Joanna;
Nakiyingi, Jessica S;
Watera, Christine;
Gilks, Charles F;
French, Neil;
Whitworth, James AG;
+1 more...Hill, Adrian VS;
(2006)
A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.
The Journal of infectious diseases, 194 (5).
pp. 666-669.
ISSN 0022-1899
DOI: https://doi.org/10.1086/505875
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We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.
