Length of hospital stay and associated treatment costs for patients with susceptible and antibiotic-resistant<i>Salmonella</i>infections: a systematic review and meta-analysis

Objectives

The global disease burden ofSalmonellainfections in 2017 included 135 900 deaths caused bySalmonellaTyphi and Paratyphi and 77 500 deaths caused by invasive non-typhoidalSalmonella, with increasing antimicrobial resistance (AMR) exacerbating morbidity, mortality and costs. The aim of our systematic review and meta-analysis is to estimate the length of hospital stay and associated treatment costs for patients with susceptible and antibiotic-resistantSalmonellaTyphi, Paratyphi and non-typhoidalSalmonellainfections.

Design

Systematic review and meta-analysis.

Data sources

We searched EMBASE, Medline/PubMed, Scopus, Hinari and LILACS databases for studies published between 1 January 2005 and 15 May 2024, with no language restrictions.

Eligibility criteria

We included 30 studies that reported the length of hospital stay or treatment costs for patients with susceptible or antibiotic-resistantSalmonellaTyphi, Paratyphi and non-typhoidalSalmonellainfections. We excluded studies with sample sizes of less than 30 patients, those focused on non-human subjects and those not reporting our outcomes of interest.

Data extraction and synthesis

Two reviewers independently screened studies and extracted data on the length of hospital stay and associated costs, with monetary values converted to 2019 USD. We aggregated data according to GDP per capita quantiles using a random-effects meta-analysis. We conducted a quality assessment using an adapted Joanna Briggs Institute tool.

Results

Patients with drug-resistantSalmonellainfections had longer hospital stays, with an additional 0.5–2.2 days compared with drug-susceptibleSalmonellainfections. Based on our meta-analysis, the mean hospital stay for typhoidalSalmonellainfections was 6.4 days (95% CI 4.9 to 7.8) for drug-susceptible cases and 8.4 days (95% CI 5.1 to 11.7) for resistant cases in the lowest income quartiles. While there were insufficient data to perform a pooled analysis, individual studies inferred that treatment costs for resistant typhoidalSalmonellainfections were higher than for susceptible infections, and resistant non-typhoidalSalmonellainfections had longer hospital stays and higher costs compared with susceptible infections. Data were scarce from high-Salmonella-burden countries, particularly in sub-Saharan Africa and parts of Asia.

Conclusions

Patients with antibiotic-resistantSalmonellainfections experience a greater healthcare burden in terms of hospitalisation length and direct costs compared with those with susceptible infections. We highlight the economic burden of AMR inSalmonellainfections and emphasise the need for preventive measures.