[Accepted Manuscript] Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.

Molloy, S.F.; Bradley, J.; Karunaharan, N.; Mputu, M.; Stone, N.; Phulusa, J.; Chawinga, C.; Gaskell, K.; Segula, D.; Ming, D.; +7 more... Peirse, M.; Chanda, D.; Lakhi, S.; Loyse, A.; Kanyama, C.; Heyderman, R.S.; Harrison, T.S.; (2018) [Accepted Manuscript] Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis. AIDS (London, England). ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0000000000001961

Abstract

: We assessed the effect of fluconazole 1200 mg/day on QT interval in cryptococcal meningitis patients. Mean QTc change from baseline to day 7 was 10.1ms (IQR: -28 to 46) in the fluconazole treatment group and -12.6ms (IQR: -39 to 13.5) in those not taking fluconazole (p = 0.04). No significant increase in QTc measurements over 500ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.